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Effectiveness of diclofenac, ketorolac and etoricoxib in the treatment.

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Use these medicines with caution in patients with risks factors for cardiovascular diseaseundertaking individual assessment of each patient to ensure the benefits outweigh the risks.

In addition to this reviewthe TGA has also completed a full safety review of diclofenac.

Similarlythe risk of hepatotoxicitycommonly known as liver damagein relation to use of prescription diclofenac was knownbut the TGA’s safety review of that medicine found that OTC diclofenac products also carried this risk.

The reviews involved evaluation of relevant medical literatureassessing input from sponsors and industry stakeholdersand obtaining expert advice from the Advisory Committee on the Safety of Medicines.

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when diclofenac is taken by mouth it passes into breast milk in very small amounts that are unlikely to be harmful to a nursing infant.